Blood and Other Tests 
• A complete blood count (CBC) reveals anemia in two-thirds of
  patients.
• An increased total serum protein may be one of the first clues to
  the presence of an M-protein. An elevated serum calcium occurs in
  about 30 percent of patients. The level of serum creatinine (a
  measure of kidney function) is abnormal in more than one-fourth of
  patients at diagnosis. The serum beta-2 microglobulin level is
  helpful in prognosis .
• Serum protein electrophoresis shows an M-protein "spike" in 80
  percent of patients. Immunoelectrophoresis or immunofixation is
  necessary to determine the type of M-protein. The amount of
  M-protein is measured by serum protein electrophoresis or by the
  measurement of IgG or IgA, the two major types of M-protein
  found in multiple myeloma .
• Ninety-nine percent of patients with multiple myeloma will have
  an M-protein in the blood or in the urine. If the level of M-protein
  in the blood is high or if the patient has blurred vision or bleeding,